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MOTS-c can regulate (i) nuclear genes, including those related to metabolism and proteostasis, (ii) skeletal muscle metabolism, and (iii) myoblast adaptation to metabolic stress

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To reflect the therapeutic intent and the need for standardised macronutrient targets, the term ‘ very-low–calorie ketogenic diet’ has been recently revised and replaced with ‘ very-low–energy ketogenic therapy (VLEKT)’, as proposed by the ‘KetoNut’ expert panel of the Italian Society of Nutraceuticals (SINut) and the Italian Association of Dietetics and Clinical Nutrition (ADI) [106]